June 25, 2025 |
5 - 8 p.m. |
Registration Continental Ballroom Foyer | BR (Ballroom Level)
Pick up your badge on June 25 and be entered to win one of three $50 Amazon gift cards.
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7:30 - 8:30 p.m. |
Welcome Event for Students (RSVP Only)
Golden Gate Ballroom (ground floor)
Hosted by Dr. Margaret Stratton, UMass Amherst, Executive Council Member, Protein Society and Dr. Elizabeth Meiering, University of Waterloo, President of The Protein Society
Take advantage of the PS39 orientation, where hosts will share insider information related to the program and opportunities offered at the meeting. Network and mingle with other attendees, including speakers and meeting organizers. Recommended for undergraduate, graduate students and postdocs, and all Travel Award winners.
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June 26, 2025 |
7:30 a.m. - 6 p.m. |
Registration Continental Ballroom Foyer | BR (Ballroom Level) |
8:45 - 9:15 a.m. |
Opening and 2024 Stein and More Award Plenary Talk Continental Ballroom 1-5
Opening and Introduction Dr. Elizabeth Meiering, University of Waterloo | President, The Protein Society 2024 Stein and More Award
Dr. Jeff W. Kelly, The Scripps Research Institute | The Scientific Origins of Drugs That Slow Neurodegeneration
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9:25 a.m. - 12:15 p.m. |
Parallel Session 1 | Continental Ballroom 1 - 5
Revealing the Invisible: New Techniques for Observing Transient Protein States
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Parallel Session 2 | Continental Ballroom 6 - 9
Emergent Properties of Protein Supramolecular Assemblies
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9:25 - 9:55 a.m. |
Elizabeth Komives, University of California San Diego | HDX-MS and NMR Reveal Allostery and Hidden Frustrated Conformations |
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Allison Williams, University of California San Francisco | Phosphorylation State Dictates Bacterial Stressosome Assembly and Function
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9:55 - 10:25 a.m. |
Shang-Te Hsu, Academia Sinica | Allosteric Coupling of Functional Dynamics of BAP1 Revealed by Methyl Nmr Spectroscopy |
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Randal Halfmann, Stowers Institute for Medical Research | Signalosome Adaptors Are Phase Change Batteries that Power Innate Immunity
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10:25 - 10:40 a.m. |
Darren Kahan, University of California Berkeley | X-Ray Footprinting / Mass Spectrometry Provides a New, Detailed View of Intrinsically Disordered Protein Structural Ensembles |
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Jan-Hannes Schaefer, Scripps Research Institute | Dissecting the Crosstalk between Transthyretin Amyloids and the Extracellular Matrix
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10:40 - 11:05 a.m. |
Coffee Break and Exhibits | Golden Gate Ballroom |
11:06 - 11:09 a.m. |
Sara Walters, Virginia Commonwealth University | Elucidating Glutathione Peroxidase 4’s Interactions for Understanding of Structure and Function
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Jake Simmons, University of North Carolina at Chapel Hill | Exploring the Diversity of Multivalent Interaction Mechanisms in Intrinsically Disordered Proteins |
11:09 - 11:12 a.m. |
Rajarshi Roy, Purdue University | Comprehensive Study of Structural Transitions between Protein Conformations via Adaptively Biased Path Optimization |
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Adam Lentz, University of California Santa Cruz | Structure of the Human Astrovirus Capsid Spike in Complex with the Neonatal Fc Receptor
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11:12 - 11:15 a.m. |
To Uyen Do, University of North Carolina at Chapel Hill | Characterizing the Sequence Determinants for Multivalent Interactions of the CITED Intrinsically Disordered Proteins with the Transcriptional Activators CBP/p300
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Ke Hou, University of California Los Angeles | How Short Peptides Can Disassemble Ultra-Stable Tau Fibrils Extracted from Alzheimer’s Disease Brain by a Strain-Relief Mechanism
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11:15 - 11:45 a.m. |
Michael Thompson, University of California Merced | Using Ultrafast X-Ray Pulses to Understand How SLO Makes Lipid Peroxidation Go Fast
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Meytal Landau, DESY | Virulent and Antimicrobial Amyloids |
11:45 a.m. - 12:15 p.m. |
Sarah Rauscher, University of Toronto | Revealing the Invisible: New Techniques for Observing Transient Protein States |
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Frederic Rousseau, Switch Laboratory, VIB-KU Leuven Center for Brain & Disease Research | Mapping the Structural Landscape and Interactome of Amyloids |
12:20 - 1:20 p.m. |
Lunch and Exhibits | Golden Gate Ballroom |
12:20 - 1:20 p.m. |
Networking Tables | Cityscape Chairs: Dr. Sheila Jaswal, Amherst College, and Dr. Margaret Stratton, U Mass Amherst
RSVP Required This networking event is a unique experience that brings students and early career attendees up close and personal with protein science veterans and peers to discuss various career and diversity, equity and inclusion topics.
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1:30 - 4:20 p.m. |
Parallel Session 3 | Continental Ballroom 1 - 5
New Proteins and Folds Through AI
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Parallel Session 4 | Continental Ballroom 6 - 9
Proteins Moving, and On the Move Inside the Cell
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1:30 - 2 p.m. |
Sarah Alamdari, Microsoft | Generative Protein Language Models |
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Sandra Encalada, The Scripps Research Institute | Endolysosomal Trafficking and in Situ Ultrastructure of Mutant Prion Protein Aggregates in Axons Reveals Hubs of Organelle-Cytoskeletal Remodeling
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2 - 2:30 p.m. |
Zhongyue Yang, Vanderbilt University | Staying Cool: Molecular Modeling-Informed Design of Cold-Adapted Bidomain Enzymes |
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Moriah Beck, Wichita State University | On the Move, Palladin at the Crossroads of Actin Branching and Bundling
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2:30 - 2:45 p.m. |
Matteo Cagiada (Protein Science Best Paper Winner), Copenhagen University | Predicting absolute protein folding stability using generative models |
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Karishma Bhasne, University of Massachusetts Amherst | Characterization of Tau Hmw-F from Human Brain Tissue and Investigation of Their Propagation
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2:45 - 3:10 p.m. |
Coffee Break and Exhibits | Golden Gate Ballroom |
3:11 - 3:14 p.m. |
Long Tran, University of Washington | De Novo Design of Fluorophore Binding Proteins |
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Cyndi Tabilo Agurto, Pontificia Universidad Catolica de Chile | Tracing the Metamorphic Behavior of Rfah through Evolution
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3:14 - 3:17 p.m. |
Lily Capeci, Georgia Institute of Technology | Engineering and De Novo Design of Lipid-Binding Proteins |
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Sachithra Senanayake, University of Nebraska-Lincoln | Resolving the 7SK RNP Interactome in-cellulo With Proximity Labeling |
3:17 - 3:20 p.m. |
Katherine Hatstat, University of California San Francisco | Engineering Bacterial Signal Transduction with Protein Design |
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Jenny Tran, Vanderbilt University School of Medicine | Elucidating the Allostery of Active Site Dynamics in α-oxoamine Synthases
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3:20 - 3:50 p.m. |
Gustav Oberdorfer, Graz University | A Hybrid Machine Learning and Atomistic Modeling Approach for the Design of de Novo Enzymes |
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Raúl Padrón, UMass Chan Medical School | Beat Generation: Molecular Structure of the Myosin Filament that Powers the Heart
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3:50 - 4:20 p.m. |
Noelia Ferruz, Centre for Genomic Regulation | Controllable Protein Design with Language Models |
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Bianxiao Cui, Stanford University | Membrane Curvature-Induced Integrin Adhesion and Mechanotransduction |
4:30 - 6:30 p.m. |
Reception: Posters and Exhibits | Golden Gate Ballroom |
June 27, 2025 |
7:30 a.m. - 6 p.m. |
Registration Continental Ballroom Foyer | BR (Ballroom Level) |
9 a.m. - 7:30 p.m. |
Professional Headshots Golden Gate Ballroom
For the first time this year, we will have a professional photographer onsite with an Executive Photo Booth at PS39. On June 27, photographers will be onsite all day for turn-key executive photos. Add some extra time in your schedule (each session takes just 1 - 2 minutes!), and you will immediately be able to select 6 - 12 portraits, and receive a private link to download all selected photos.
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8:45 - 9:15 a.m. |
2025 Carl Branden Plenary Award Talk Continental Ballroom 1 - 5
2025 Carl Branden Award Dr. James Fraser, University of California, San Francisco | Statistical Structural Biology and More Transparent Science
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9:25 a.m. - 12:15 p.m. |
Parallel Session 5 | Continental Ballroom 1 - 5
Enzyme Catalysis: Mechanistic Insights From Structure, Computation and Evolution
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Parallel Session 6 | Continental Ballroom 6 - 9
Proteostasis and Protein Quality Control
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9:25 - 9:55 a.m. |
Mark Wilson, University of Nebraska-Lincoln | Electrostatically Gated Enzyme Dynamics during Catalysis |
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Henry Colecraft, Columbia University | Hacking the Ubiquitin Code to Control Ion Channel Expression for Therapy
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9:55 - 10:25 a.m. |
Mary Jo Ondrenchen, Northeastern University | Prediction of Effects of Missense Mutations on Biochemical Function of Enzymes
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Kalle Gehring, McGill University | A Molecular Glue for Parkin |
10:25 - 10:40 a.m. |
Jessica Lusty Beech (Protein Science Best Paper winner), Montana State University | Understanding the stability of a plastic-degrading Rieske iron oxidoreductase system |
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Yingzi Xia, Johns Hopkins University | Unraveling the Complexity of Protein Folding: A Structural Characterization of Misfolded E.coli Phosphoglycerate Kinase |
10:40 - 11:05 a.m. |
Coffee Break and Exhibits | Golden Gate Ballroom |
11:06 - 11:09 a.m. |
Yuda Chen, University of California San Francisco | Emergence of Specific Binding and Catalysis from a De Novo Designed Generalist Binding Protein |
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Francesco Gregoris, University of Padua | Vhl Isoforms unveiled: Dual Roles in Androgen Receptor Regulation and Clear Cell Renal Cell Carcinoma (ccRCC) Aggressivity
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11:09 - 11:12 a.m. |
Nadia Hyatt, Drexel University College of Medicine | Resolving the Molecular Details that Regulate Type-A Vancomycin Resistance
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Jashanjot Kaur Gill, University of Western Ontario | Post-Translational Control of E2 Conjugating Enzymes
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11:12 - 11:15 a.m. |
Lian Duan, University of Tsukuba | PaCS-Q: New Accelerated QM/MM MD for Enzymatic Reaction Path Sampling |
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Emily Schaffter, Clark University | Differential Interactions Between Calmodulin and the IQ Motifs of the HECT E3 Ubiquitin Ligases UBE3B and UBE3C
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11:15 - 11:45 a.m. |
Amie Boal, The Pennsylvania State University | The Periodic Table of Ribonucleotide Reductases |
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Judith Frydman, Stanford University | Molecular Origami: Protein Folding and Misfolding in the Eukaryotic Cytosol
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11:45 a.m. - 12:15 p.m. |
Nobuhiko Tokuriki, The University of British Columbia | Evolutionary Dynamics of New Enzymes and Metabolic Pathways |
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Russell DeBose-Boyd, UT Southwestern | UBIAD1, a Vitamin K Synthetic Enzyme that Moonlights as a Regulator of Cholesterol Synthesis
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12:20 - 1:20 p.m. |
Lunch and Exhibits | Golden Gate Ballroom |
12:20 - 1:20 p.m. |
Protein Science Journal Workshop (RSVP only) | Plaza Ballroom A
Effective Strategies for Writing and Publishing in Protein Science
Join Editor-in-Chief Dr. John Kuryian and his editorial team as they discuss what makes a paper great for Protein Science. You’ll come away with a better understanding of the submission and publication process, insights into what the editors look for in a research paper, and how you can strengthen your submission to Protein Science.
Organizer: Margaret Donnelly, Senior Publisher, Wiley
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12:20 - 1:20 p.m. |
Educator's Panel (RSVP only) | Plaza Ballroom B
Teaching Biochemistry through Research with the BASIL Curriculum
BASIL stands for Biochemistry Authentic Scientific Inquiry Lab. The BASIL curriculum is designed for the undergraduate biochemistry lab, where students use computational tools to predict protein function and then move to the bench to express and purify their proteins and test their hypotheses. In the educator’s workshop, we will begin with a 30-minute description of the flexible implementation of our curriculum and then spend the remaining time exploring some of the computational tools we use to predict protein function.
Organizer: Paul A. Craig, Rochester Institute of Technology
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1:30 - 4:20 p.m. |
Parallel Session 7 | Continental Ballroom 1 - 5
Protein Nanopores: Sequencing and Sensing |
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Parallel Session 8 | Continental Ballroom 6 - 9
Proteins and Lipids: Fusion, Fission, Budding
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1:30 - 2 p.m. |
Bill DeGrado, University of California San Francisco | De Novo Protein Design of Functional Proteins |
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Sarah Veatch, University of Michigan | Lipids Facilitate Protein Assembly at Membranes through Prewetting
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2 - 2:30 p.m. |
Marco Mravic, The Scripps Research Institute | De Novo Design of Stable, Specific Complexes to Modulate Membrane Protein Structure and Function
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Lauren Jackson, Vanderbilt University | Membrane Remodeling by Endosomal Coat Complexes |
2:30 - 2:45 p.m. |
Fabio Gonzalez, University of Delaware | Emerging Roles of Selenoproteins in Protein Quality Control Derived through Cryo-Em |
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Xinyi Chen, Stanford University | TRANSFER: Programmable Protein Delivery via Engineered Trogocytosis |
2:45 - 3:10 p.m. |
Coffee Break and Exhibits | Golden Gate Ballroom |
3:11 - 3:14 p.m. |
Deepa Singh, All India Institute of Medical Sciences | Interaction of SCoV-2 NSP7 or NSP8 Alone with NSP12 Causes Constriction of the RNA Entry channel: Implications for Novel RdRp Inhibitor Drug Discovery
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Malvin Forson, City University of New York | Mechanistic Studies of Integrated Light and Temperature Responses in BcLOV4 |
3:14 - 3:17 p.m. |
Rachi Panchal, University of Calgary | Breaking Down the Mechanisms Behind Pain-Signalling by Investigating Voltage-Gated Sodium Channel Regulation at the I-II Loop |
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Sophie Shoemaker, University of California Berkeley | An Early Fixed Mutation in SARS-CoV-2 Spike Compensates for Increased Dynamics Induced by Furin Cleavage
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3:17 - 3:20 p.m. |
Khrishnakoli Adhikary, College of Staten Island, CUNY | Structural Characterization and Interaction of a Tarantula Peptide Neurotoxin with Voltage-Gated Sodium Channels and Lipid Membranes
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Mai Kugawa, University of Tokyo | Structural Insights Into Allosteric Activation and Inactivation Mechanisms of FFA2 |
3:20 - 3:50 p.m. |
Yujia Qing, University of Oxford | Towards Nanopore Proteomics: Single-Molecule Detection of Post-Translational Modifications on Full-Length Proteins |
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Brett Collins, The University of Queensland | Structural Basis for Coupling of the Wash Subunit FAM21 with the Endosomal SNX27-Retromer Complex
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3:50 - 4:20 p.m. |
Min Chen, University of Massachusetts Amherst | Tracking Protein Dynamics & Discovering Allosteric Modulators Using Nanopore Tweezers |
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Abdou Rachid Thiam, Ecole Normale Superieure | Synergistic Protein Targeting to Lipid Droplets for Enhanced Lipid Storage |
4:30 - 6:30 p.m. |
Reception: Posters and Exhibits | Golden Gate Ballroom |
June 28, 2025 |
7:30 a.m. - 6 p.m. |
Registration Continental Ballroom Foyer | BR (Ballroom Level) |
7:45 - 8:30 a.m. |
TPS Business Meeting/New Member Breakfast (RSVP only) | Vista |
8:45 - 9:15 a.m. |
2025 Marie Maynard Daly Award Plenary Talk | Continental Ballroom 1 - 5
Introduction: 2025 Marie Maynard Daly Award Dr. Yuh Min Chook, UT Southwestern Medical Center
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9:25 a.m. - 12:15 p.m. |
Parallel Session 9 | Continental Ballroom 1 - 5
Form and Function from Membraneless Organelles
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Parallel Session 10 | Continental Ballroom 6 - 9
Machinery and Mechanisms for Cell Death
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9:25 - 9:55 a.m. |
Dek Woolfson, University of Bristol | Designing Peptides and Proteins for New Subcellular Functions |
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Daniel Bachovchin, Memorial Sloan Kettering Cancer Center | Activation of the NLRP1 Inflammasome
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9:55 - 10:25 a.m. |
Rebecca Berlow, University of North Carolina at Chapel Hill | Exploring the Diversity of Multivalent Interaction Mechanisms in Intrinsically Disordered Proteins |
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Peter Czabotar, WEHI (Lorne Partner Speaker) | Exploring Strategies to Target BCL-2 Family Executioner Proteins to Manipulate Apoptosis
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10:25 - 10:40 a.m. |
Roman Fabry, Arizona State University | Programmable Formation of Synthetic Biomolecular Condensates in Vitro and in E. Coli via Metalloporphyrin-Driven Coiled-Coil Assembly
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Yizhi Yuan, University of Oxford | Chemoproteomic Discovery of a Human RNA Ligase for RNA Repair |
10:40 - 11:05 a.m. |
Coffee Break and Exhibits | Golden Gate Ballroom |
11:06 - 11:09 a.m. |
Noah Graves, University of New South Wales | Using Binding Affinity of GFP-Tagged HSPs to Alpha-Synuclein Strains |
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Andrew Goring, University of California Los Angeles | Hemophore-Mediated Mechanism of Heme Acquisition in Corynebacterium Diphtheriae Elucidated through Novel Approaches in Native Mass Spectrometry
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11:09 - 11:12 a.m. |
Samara Cummings, Brown University | Structural Study of Fused in Sarcoma Aggregation Caused by ALS Mutations
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Shwetha Sreenivasan, University of Kansas Medical Center | Dissecting the Effects of Single Amino Acid Substitutions in SARS-CoV2 Mpro
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11:12 - 11:15 a.m. |
Ethan Shields, Colorado State University | Biomolecular Co-Crystals as Scaffolds for DNA Binding Proteins |
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Sparsh Makhaik, University of Massachusetts, Amherst | The Role of MTL Domain in Chikungunya Virus Protease nsP2 |
11:15 - 11:45 a.m. |
Keren Lasker, The Scripps Research Institute | The Popz Condensate: From Regulation of Asymmetry in Bacteria to Synthetic Applications in Human Cells
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Doryen Bubeck, Imperial College London | Controlling the Membrane Attack Complex |
11:45 a.m. - 12:15 p.m. |
Carlos Castañeda, Syracuse University | Transient Helices in Disordered Regions Mediate Self-Association and Phase Separation of Dsk2
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Olivier Julien, University of Alberta | Defining the Role of Proteolysis in Living & Dying Cells |
12:20 - 1:20 p.m. |
Lunch and Exhibits | Golden Gate Ballroom |
12:20 - 1:20 p.m. |
Undergrad Research Session | Plaza Ballroom A (RSVP Only)
Speakers: Celeste Rodriguez, University of Texas at Austin | Norra Anpree, Chapman University | Greta Jerliu, CUNY Brooklyn College | Julie Tran, Wichita State University | Shioban Connolly, Clark University
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1:30 - 5 p.m. |
Plenary Awards and Best Poster Presentations | Continental 1 - 5 |
1:30 - 2 p.m. |
2025 Stein & Moore Award Plenary Talk Introduction
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2 - 2:30 p.m. |
2025 Protein Science Young Investigator Award Plenary Talk Introduction
2025 Protein Science Young Investigator Award Dr. Christopher Barnes, Stanford University |
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2:30 - 3 p.m. |
2025 Christian B. Anfinsen Award Plenary Talk Introduction
2025 Christian B. Anfinsen Award
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3 - 3:20 p.m. |
Coffee Break and Exhibits | Golden Gate Ballroom |
3:20 - 3:50 p.m. |
2025 Protein Science Young Investigator Award Plenary Talk Introduction
2025 Protein Science Young Investigator Award Dr. Jamie Spangler, Johns Hopkins School of Medicine |
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3:50 - 4:20 p.m. |
2025 Dorothy Crowfoot Hodgkin Award Plenary Talk Introduction: Dr. Joseph Ferrara, Rigaku Americas
2025 Dorothy Crowfoot Hodgkin Award Dr. Andy LiWang, University of California Merced | How Proteins Tell Time: Mechanistic Insights into the Cyanobacterial Circadian Clock
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4:20 - 4:50 p.m. |
2024 Protein Science Young Investigator Award Plenary Talk Introduction
2024 Protein Science Young Investigator Award Dr. Gabriela Schlau-Cohen, MIT | Why Don't Plants Get Sunburn?
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4:50 - 5 p.m. |
Best Poster Competition Winners | Dr. Kay Perry, Cornell University; and Dr. Meghan Breen, Furman University |
5 - 7 p.m. |
Reception: Posters and Exhibits | Golden Gate Ballroom
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8:30 - 10:00 p.m. |
Standing Up For Science Reception (RSVP Only) | Plaza Ballroom A & B |
June 29, 2025 |
8 - 11:30 a.m. |
Registration Continental Ballroom Foyer | BR (Ballroom Level) |
8:45 - 11:25 a.m. |
Parallel Session 11 | Continental Ballroom 1 - 5
Mechanisms of Circadian Clocks Session Chair: Dr. Andy Liwang, University of California Merced
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Parallel Session 12 | Continental Ballroom 6 - 9
20 Amino Acids… and Beyond |
8:45 - 9:15 a.m. |
Deborah Bell-Pedersen, Texas A&M University | Adaptiveness of the Temperature-Dependent Energy Landscape of the Metamorphic Circadian Clock Protein, KaiB
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Klara Hlouchova, Charles University | Could Early Proteins do Without All 20 |
9:15 - 9:45 a.m. |
Margaret Cheung, Pacific Northwest National Laboratory | Transcriptome and Redox Proteome Reveal Temporal Scales of Carbon Metabolism Regulation in Model Cyanobacteria under Light Disturbance
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Bobo Dang, Westlake University | Natural Amino Acid Based Bioorthogonal Protein Chemistry
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9:45 - 10 a.m. |
Mingxu Fang, The Ohio State University | In Vitro Circadian Gene Expression
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Lasya Vankayala, University of Oxford | The Nanobondy Format for Irreversible Immune Cell Decoration through Neisslock Coupling |
10 - 10:15 a.m. |
Coffee Break and Exhibits | Continental Ballroom Foyer |
10:16 - 10:19 a.m. |
Jiwoo Hwang, Case Western Reserve University | Mass Spectrometry Reveals Age-Dependent Methionine Sulfoxide Speciation in Actin and Calmodulin Derived From Mouse |
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Atif Shafique, Northeastern University | How Do Catalytic lysines, Aspartates and Glutamates in Enzymes Gain Their Catalytic properties? |
10:19 - 10:22 a.m. |
Katerina Martinez, University of California Merced | Fold-Switching KaiB: Key to Cyanobacterial Clock Shutdown at Low Temperatures
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Eva Gerber, University of California Berkley | Probing Protein Energy Landscapes in High Throughput
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10:22 - 10:25 a.m. |
TBD |
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Evrim Fer, University of Wisconsin-Madison | Universal Gtpases Reveal Translation Evolution before the Last Universal Common Ancestor
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10:25 - 10:55 a.m. |
Jennifer Hurley, Rensselaer Polytechnic Institute | A Role for Intrinsic Protein Disorder in Circadian Post-Transcriptional Regulation |
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Dustin King, Simon Fraser University | CO2-Dependent Protein Carbamate Formation: A Biochemical Mechanism for CO2 Sensing
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10:55 - 11:25 a.m. |
Megan Torgrimson, University of California Santa Cruz | Post-translational Signal Integration by CK1 on the Clock Protein PER2 |
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Alanna Schepartz, University of California Berkley | Protein Editing Three Ways |
11:35 a.m. - 1:15 p.m. |
Plenary Awards and Closing | Continental Ballroom 1 - 5 |
11:35 a.m. - 12:05 p.m. |
2025 Hans Neurath Award Plenary Talk Introduction
2025 Hans Neurath Award Dr. Antonina Roll-Mecak, NINDS/National Institutes of Health |
12:05 - 12:35 p.m. |
2025 Emil Thomas Kaiser Award Plenary Talk Introduction
2025 Emil Thomas Kaiser Award Dr. Brian Kuhlman, University of North Carolina, Chapel Hill
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12:35 - 1:05 p.m. |
2024 Hans Neurath Award Plenary Talk Introduction
2024 Hans Neurath Award Dr. David Cortez, Vanderbilt University | Maintaining Genome Stability: Challenges and Solutions |
1:05 - 1:15 p.m. |
Service Awards and Closing, Dr. Elizabeth Meiering, University of Waterloo | President, The Protein Society |