| 9 - 11:55 a.m. |
Parallel Session 1 | Macromolecular Complexes in Biology
Grand Ballroom CDE
|
Parallel Session 2 | Engineering Protein Biologics
Grand Ballroom AB
|
| 9:05 - 9:35 a.m. |
Erica Ollmann Saphire, La Jolla Institute for Immunology | New Antibodies Against an Old Threat - The Structural Roadmap |
Tanja Kortemme, University of California San Francisco | De novo Design of Programmable Protein Dynamics |
| 9:35 - 10:05 a.m. |
Kai (Jack) Zhang, University of Science & Technology of China | High-resolution in situ Cryo-EM of Complexes within Mitochondria & Chloroplasts |
Shohei Koide, New York University | Direct & Selective Targeting of Cancer-driver Mutants With Synthetic Binding Proteins |
| 10:05 - 10:20 a.m. |
Juan Caceres Vergara, HHMI/MIT | Cryo-EM snapshots of Ribonucleotide Reductase Inhibition by the Anticancer Agent Gemcitabine Diphosphate |
Valeria Italia, M.P.G Instruments | Tuning Protein-Based Materials Through Control of Early Assembly Conditions |
| 10:20 - 10:45 a.m. |
Coffee Break and Exhibits | Grand Ballroom Foyer & Outdoor Pavilion |
| 10:46 - 10:49 a.m. |
Laura Nataly Lozano, Universidad Nacional Autónoma de México |
Biochemical Characterization of a Recombinant Chimeric Antigen from Mycobacterium tuberculosis Produced in Pichia pastoris (Komagataella phaffii) |
Montserrat Escobar-Rosales, Universitat Ramon Llull | Engineering a Generalizable Strategy for Conditionally-active Biotherapeutics via de novo Peptide Mask Design |
| 10:49 - 10:52 a.m. |
Casey Wing, University of Texas Southwestern Medical Center | Intrinsic XPO1 Allostery Determines Whether Inhibitors Block Export or Drive ASB8-Dependent Degradation |
Foster Birnbaum, MIT | StructMPNN: A Next-generation Sequence Design Model That Learns Many-to-Many Sequence-Structure Mappings by Supervising Foldability |
| 10:52 - 10:55 a.m. |
Motahareh Ghahari Larimi, National Institutes of Health | Structural Studies of SARS-CoV-2 Nucleocapsid Protein RNA Complexes |
Hanzhi Zhang, AstraZeneca | HDX-MS-Guided Computational Modeling for Rapid and Accurate Antibody-Antigen Interface Mapping |
| 10:55 - 11:25 a.m. |
Ruchi Anand, Indian Institute of Technology | Combatting Ribosomal Methylation Based Antibiotic Resistance: A War at the Microscopic Level |
Lindsay Hammack, Merck | De Novo Designed Protein Agonist Targeting a Heterodimer With-out a Solved Structure |
| 11:25 - 11:55 a.m. |
Kendra Frederick, University of Texas Southwestern Medical Center | Determining Protein Conformations Inside Cells Using DNP-Enhanced Solid-State NMR |
Dane Wittrup, MIT | Knotpin Libraries: Diverse b-hairpin Paratopes Grafted Into knottin/ cyclotide Scaffolds |
| 12 - 1:30 p.m. |
Workshop and Exhibits | Commonwealth Ballroom, Grand Ballroom Foyer & Outdoor Pavillion |
| 12:15 - 1:25 p.m. |
Networking Tables (RSVP Required) | Commonwealth Ballroom
Chairs: Dr. Margaret Stratton, University of Massachusetts Amherst
This networking event is a unique experience that brings students and early career attendees up close and personal with protein science veterans and peers to discuss various topics. Table leaders include Dr. Anne Gershenson, Program Director, NIH and the Community, Action and Opportunity Committee. |
| 1:30 - 4:30 p.m. |
Parallel Session 3 | Protein Allostery & Biophysics
Grand Ballroom AB |
Parallel Session 4 | Protein Nanotechnology
Grand Ballroom CDE |
| 1:35 - 2:05 p.m. |
Breann L. Brown | Vanderbilt University | Uncovering the Role of Protein Structure and Dynam-ics in the Regulation of Heme Biosynthesis |
Alena Khmelinskaia, Ludwig-Maximilians-Universität München | Function-driven Design of Protein Assemblies |
| 2:05 - 2:35 p.m. |
Vincent J. Hilser | Johns Hopkins University | A Code For Ensemble Molecular Mimicry & Antibody Cross-reactivity |
Jin Montclare, New York University | Designing Protein-Based Nanomaterials: From Sequence to Functional Biomaterials |
| 2:35 - 2:50 p.m. |
Harrison Wang, Harvard University | Atomic-resolution Observation of Force Propagation in a Human Enzyme |
Gabriela Guedes, University of Cambridge | Engineered CTPR Protein Scaffolds-Based Nanoparticles as Versatile Ther-anostic Agents |
| 2:50 - 3:20 p.m. |
Coffee Break and Exhibits | Commonwealth Ballroom |
| 3:22 - 3:24 p.m. |
Anna Bock, Brown University | Atomic-level Insights Into Long-range Effects of Specificity Enhancing Mutations on the Active Site of CRISPR-Cas9 HNH Nuclease |
Caroline Slaughter, Colorado State University | Enzymatic Ligation & Restriction for Dynamic Reconstruction of Biomolecular Co-Crystals |
| 3:24 - 3:26 p.m. |
Lee Schnaider, UCSF | Enfolds: Stimuli-Responsive Protein Switches for Cue-Gated Bioactive Peptide Masking and Release |
Taner Karagöl, Istanbul University | Systematic Redesign of Synaptic Vesicle Proteins into Water-Soluble Variants via the QTY-Code Reveals Key Conformational & Evolutionary Dynamics |
| 3:26 - 3:28 p.m. |
Nirsanka Roy, Arizona State University | Watching EGFR Signaling With Single Molecule FRET |
Rama Edaibis, University of Toronto | Developing Next-Generation Drugs from Designer Proteins |
| 3:28 - 3:30 p.m. |
Susu He, Dartmouth College | Cysteine Sensing Allostery of CifR, a TetR Regulator of the Virulent epoxide hydrolase Circuit in Pseudomonas aeruginosa |
|
| 3:30 - 4 p.m. |
Lakshmi Wijeyewickrema, La Trobe University (Lorne exchange Speaker) | Exosites Are Exciting: Recognition Beyond the Active Site Governs C2 Activation & Inflammatory Amplification in Complement |
Pascal Lill | Cube Biotech | Membrane Proteins at Scale: Automated Copolymer Nano-disc Purification for Structure & Function |
| 4 - 4:30 p.m. |
Julien Roche, Iowa State University | High-pressure NMR Study of Biological Systems |
Adam Caparco, Northeastern University | Protein Nanoas-semblies for Biocatalysis and Nucleic Acid Delivery |
| 4:30 - 6:30 p.m. |
Reception: Posters and Exhibits | Grand Ballroom Foyer & Outdoor Pavilion |
| Monday, June 20 |
| 8 a.m. - 4 p.m. |
Registration | Grand Ballroom Foyer | (Concourse Level) |
| 8:15 - 8:50 a.m. |
TPS Business Meeting/New Member Breakfast (RSVP Required) | Commonwealth Ballroom |
| 9 - 11:55 a.m. |
Parallel Session 5 | Function & Behavior of Intrinsically-Disordered Proteins
Grand Ballroom CDE |
Parallel Session 6 | Machine Learning and AI in Protein Science
Grand Ballroom AB |
| 9:05 - 9:35 a.m. |
Priya Banerjee, University at Buffalo | From Sequence to Selectivity: How Disordered Prion-Like Domains Orchestrate Co-Condensation of Transcrip-tional Regulators |
Stephanie Wankowicz, Vanderbilt University | From Possibility to Precision in Macro-molecular Ensemble Prediction |
| 9:35 - 10:05 a.m. |
Andrea Soranno, Washington University | Single-molecule Spectroscopy of Disordered Regions and Nucleic Acids in Bacterial Transcription |
Minkyung Baek, Seoul National University | AI-based Antigen–Antibody Complex Structure Prediction and Design |
| 10:05 - 10:20 a.m. |
Mriganka Parasar, MIT | Investigating Tau Fibrillization Intermediates Using 19F and 13C Solid-State NMR |
Susan Tsutakawa, Lawrence Berkeley National Laboratory | AlphaSAXS: Integrating OpenFold with Physiologically Relevant Conformations from X-ray Scattering Data |
| 10:20 - 10:45 a.m. |
Coffee Break and Exhibits | Grand Ballroom Foyer & Outdoor Pavilion |
| 10:46 - 10:49 a.m. |
Clarice Stumpf, University of Massachusetts Amherst | Automated Protocol For Large-Scale Reconstruction of Amyloid Fuzzy Coats |
Zheyu Zhang, Northeastern University | Large Language Models for Ligand Annotation in the Protein Data Bank: A Benchmark Study |
| 10:49 - 10:52 a.m. |
Marisa Barilla, Yale University | Protective Mechanisms of CAHS IDPs in Tardigrades |
Emma Magna, Colorado State University | Computational Protein Design for a Novel Porous DNA-Protein Co-Crystal |
| 10:52 - 10:55 a.m. |
Nora Jaber, Rutgers University | Protein-Membrane Interactions in Cell-to-Cell Transmission of Huntingtin Protein |
Zhihui Qi, Harvard University | Inferring Protein Dynamics from Evolutionary Sequence Embeddings |
| 10:55 - 11:25 a.m. |
Rebecca Berlow | University of North Carolina | Uncovering
Hidden Conformations & Functions of Intrinsically Disordered Proteins |
Kuen-Phon Wu | Academia Sinica | Mesostructured Water Enhances Stability of AI-de-signed Proteins |
| 11:25 - 11:55 a.m. |
Ute A. Hellmich | Friedrich Schiller University | Regulation Through Disorder: Lipid Signalling Through Unstructured Regions Shapes Ion Channel Function in Health & Disease |
Jean-Philip Piquemal, Sorbonne Universite | A Quantum Foundation Model for Accurate Atomistic Simulations in Drug Design |
| 12 - 1:30 p.m. |
Workshop and Exhibits | Commonwealth Ballroom, Grand Ballroom Foyer & Outdoor Pavillion |
| 12:15 - 1:25 p.m. |
Protein Science Journal Workshop (RSVP Required) | Commonwealth Ballroom
Effective Strategies for Writing and Publishing in Protein Science
Join Editor-in-Chief Dr. John Kuryian and his team of Senior Editors and Associate Editors as they discuss what makes a paper great for Protein Science. You’ll come away with a better understanding of the submission and publication process, insights into what the editors look for in a research paper, and how you can strengthen your submission to Protein Science.
Organizers: Margaret Donnelly, Senior Publisher, Wiley and John Kuriyan, Editor in Chief, Protein Science |
| 1:30 - 4:30 p.m. |
Parallel Session 7 | Cellular Protein Dynamics & Distribution
Grand Ballroom CDE |
Parallel Session 8 | Physics-based Computation in Protein Science
Grand Ballroom AB |
| 1:35 - 2:05 p.m. |
Lisa M. Jones, University of California San Diego | Characterizing Drug Downstream and Off Target Effects Using Proteome-Wide Structural Biology |
Joan-Emma Shea, University of California Santa Barbara | Self-Assembly of the Tau Protein: Liquid-Liquid Phase Separation and Fibrillization |
| 2:05 - 2:35 p.m. |
Masaharu Somiya, Tohoku University | Post-translational Editing of Protein sequences |
Dan Herschlag, Stanford University | Ensemble-function Analysis Accounts for Mysteries of Phosphoryl Transfer Catalysis:
Transitioning From Empirical Analyses to Physics-based Evaluation |
| 2:35 - 2:50 p.m. |
Raibat Sarker, Yale University | WW Domain Folding in Living Cells |
George Wanes, Northeastern University | Physical-Chemical Principles of Ribosome Dynamics in Translation & Trans-Translation |
| 2:50 - 3:20 p.m. |
Coffee Break and Exhibits | Grand Ballroom Foyer & Outdoor Pavillion |
| 3:21 - 3:24 p.m. |
Moriah Beck, Boston College | Condensates as Cytoskeletal Control Centers: Palladin’s Emerging Role in Actin Dynamics |
Virginia Jiang, Princeton University | A Multiscale Framework For Designing Synthetic Membrane-associated Condensates as Microreactors |
| 3:24 - 3:27 p.m. |
Isaac Paddy, Stanford School of Medicine | Deciphering the Molecular and Structural Framework of Bacterial HMG-CoA Reductases in Isoprenoid Biosynthesis |
Yousuf Ramahi, University of Toronto | Changes in Protein Dynamics Quantified By Inter-residue Contact Lifetimes: A Molecular Dynamics Simulation Analysis |
| 3:27 - 3:29 p.m. |
Ruth Adafia, University of Massachusetts Amherst | Using Cryo-EM to Decipher Calcium Sensitivity of CaMKII Variants |
Jacopo Zattoni, University of Alberta | Coordination & Energetics of tRNA Hybrid State Formation in the Yeast 80S Ribosome |
| 3:30 - 4 p.m. |
Abhishek Chatterjee, Boston College | Engineering Aminoacyl-tRNA Synthetases for Introducing Novel Backbones Into Proteins in Living Cells |
Carol B. Post, Purdue University | Atomistic Mechanism of a Unique Entropy-driven Allosteric Mechanism to ‘Tone Down’ High Affinity Binding of Syk Kinase to Membrane Receptors |
| 4 - 4:30 p.m. |
Elizabeth Hinde | University of Melbourne | Tracking the Impact of Protein Complex Formation on Protein Transport Dynamics in Live Cells |
Benoit Roux | University of Chicago | Theoretical & Computational Treatments of Molecular Binding in the Context of Lipid Membranes |
| 4:30 - 6:30 p.m. |
Reception: Posters and Exhibits | Grand Ballroom Foyer & Outdoor Pavilion |
| Tuesday, July 21 |
| 8 a.m. - 4 p.m. |
Registration | Grand Ballroom Foyer | (Concourse Level) |
| 8:30 - 11:25 a.m. |
Parallel Session 9 | New Problems in Protein Folding | Grand Ballroom AB |
Parallel Session 10 | Proteins At the Membrane | Grand Ballroom CDE |
| 8:35 - 9:05 a.m. |
Tobin Sosnick, University of Chicago | Structural Energetics as a Framework for Rationalizing Protein Function |
Rosemary Cater, University of Queensland | Structural & Molecular Basis of Choline Uptake Into the Brain by FLVCR2 |
| 9:05 - 9:35 a.m. |
Brian F. Volkman, Medical College of Wisconsin | Cold Denaturation in the Adaptive Evolution of Metamorphic Proteins |
Camilo Perez, University of Georgia | Mechanistic Basis of Transport Processes in Bacterial Cell Wall Biopolymer Synthesis |
| 9:35 - 9:50 a.m. |
Kathryn Shelley, University of Washington | De novo Design of Light-driven Protein Motor Domains |
Grace Baron, California Institute of Technology | The Structure of the Lipid II flippase From E. coli in a Native Lipid Environment |
| 9:50 - 10:15 a.m. |
Coffee Break and Exhibits | Grand Ballroom Foyer & Outdoor Pavillion |
| 10:16 - 10:19 a.m. |
Juaneisha Finnie, University of Virginia | Signal Peptides Govern Effective Targeting, Folding, & Insertion of Outer Membrane Proteins in the E. coli Outer Membrane |
Ryan Singer, University of Michigan | Engineering Genetically-Encoded Tools for Activation of Endogenous Melanocortin Receptors With High Spaciotemporal Resolution |
| 10:19 - 10:22 a.m. |
Ian Neidigh, Yale University | Quantifying Protein Folding & Dynamics of VlsE in Differentiated Tissues of Living Zebrafish Embryos |
Momono Yamauchi, Kyoto University | Structural Insights Into the G Protein Subtype Selectivity Revealed by Human Sphingosine-1-Phosphate Receptor 3-Gq Complexes |
| 10:22 - 10:25 a.m. |
Mohammad Shamsi, Ajman University | Molecular & Biophysical Insights into the Interaction of Hordenine with Human Lactoferrin |
Phuc Phan, University of Arkansas | PKC Phosphorylation Modulates Kv7.2–Calmodulin Interactions |
| 10:25 - 10:55 a.m. |
Stephen Fried, Johns Hopkins University | Protein Folding in the AI Era: What’s Left to Discover? |
Ming-Feng Tsai, University of Virginia | Molecular Mechanisms of Mitochondrial Calcium Transport |
| 10:55 - 11:25 a.m. |
Duyoung Min, Ulsan National Institute of Research | Single-molecule Tweezers Decode Hidden Patterns of Membrane Protein Folding & Interactions |
Brian Fuglestad, Virginia Commonwealth University | Molecular Control of Proteins at the Membrane Interface |
| 11:25 a.m. - 12:35 p.m. |
Workshop and Exhibits | Commonwealth Ballroom, Grand Ballroom Foyer & Outdoor Pavillion |
| 11:30 a.m. - 12:30 p.m. |
Undergrad Research Session (RSVP Required) | Commonwealth Ballroom
Chair: Dr. Matthew Gage, University of Massachusetts Lowell
Speakers: Ivan Escobar-Chavez, Centro de Investigacion en Alimentacion y Desarrollo | Sydney Mager, University of Massachusetts Amherst | Mary Harutyunyan, University of Massachusetts Lowell | KC Gabriel, Yale University |
| 12:35 - 3:25 p.m. |
Plenary Awards and Best Poster Presentations | Grand Ballroom |
| 12:35 - 12:45 p.m. |
2025 and 2026 Fellows | Heather Pinkett, Northwestern University | President, The Protein Society |
| 12:45 - 1:15 p.m. |
2026 Protein Science Young Investigator Award
Laura Dassama, Stanford University | |
| 1:15 - 1:45 p.m. |
2026 Marie Maynard Daly Award
Stephen Fesik, Vanderbilt University | |
| 1:45 - 1:55 p.m. |
Martin Karplus Award, Marci Karplus |
| 1:55 - 2:20 p.m. |
Coffee Break and Exhibits | Grand Ballroom Foyer & Outdoor Pavillion |
| 2:20 - 2:50 p.m. |
2026 Hans Neurath Award
Charalampos Babis Kalodimos, St. Jude Children's Research Hospital | |
| 2:50 - 3:20 p.m. |
2026 Emil Thomas Kaiser Award
Peng Chen, Peking University | |
| 3:20 - 3:30 p.m. |
Best Poster Competition Winners | Dr. Kay Perry, Cornell University; and Dr. Meghan Breen, Furman University |
| 3:30 - 5:30 p.m. |
Reception: Posters and Exhibits | Grand Ballroom Foyer & Outdoor Pavilion |
| 6 - 7 p.m. |
PS40 Reception, hosted by AI Proteins (RSVP Required) |
One Kenmore Square (Citgo Building) |
| 7:10 p.m. |
Baseball Game (RSVP and Tickets Required) | Fenway Park |
| Wednesday, July 22 |
| 8 - 11:30 a.m. |
Registration | Grand Ballroom Foyer |
| 8:30 - 11:20 a. m. |
Parallel Session 11 | Proteins Evolution
Grand Ballroom AB |
Parallel Session 12 | Proteins in Agriculture
Grand Ballroom CDE |
| 8:35 - 9:05 a.m. |
Mike Harms, University of Oregon | The Evolution of Multi-con-formation Proteins |
Katie Stewart, Corteva Agriscience | Plant Derived Insecti-cidal Proteins for Protection of Crop Plants |
| 9:05 - 9:35 a.m. |
Anum Glasgow, Columbia University | Evolutionary Conservation of Functional Allostery in Protein Families |
Sheng Yang He, HHMI/Duke University | Phytopathogen Virulence Proteins as Targets for Disease Control |
| 9:35 - 9:50 a.m. |
Hannes Ludewig, HHMI, Brandeis University | Comparing the Evolvability of an Ancestrally Reconstructed & Modern Adenylate kinase |
|
| 9:50 - 10:15 a.m. |
Coffee Break | Grand Ballroom Foyer |
| 10:16 - 10:19 a.m. |
Farah Haque, Massachusetts General Hospital and Harvard Medical School | Repurposing the Kinesin Fold: How KIF7 Adapts Conserved Kinesin Design Principles for its Function in Hedgehog Signaling |
Milena Dobronos, Okinawa Institute of Science and Technology (OIST) | Biochemistry and Evolution of Central Carbon Metabolism in MarineOligotrophic Bacteria |
| 10:19 - 10:22 a.m. |
Stephanie Halim, Massachusetts Institute of Technology | Upregulated Chaperone Networks in Cancer Increase p53’s Mutational Tolerance |
|
| 10:22 - 10:25 a.m. |
Alper Karagöl, Istanbul University, Istanbul Faculty of Medicine | Multi-level Comparative Analysis Reveals Evolutionary Influence of Truncated Isoforms in Glutamate Transporters |
|
| 10:25 - 10:55 a.m. |
Colin Jackson | Australian National University | Enthalpyentropy Trade-offs in the Evolution of Ligand Specificity in a Super-family of Transcription Factors |
Christopher Fleming, Syngenta | Beyond Nature's Arsenal: Engineering the Next Generation of Insecticidal Proteins |
| 10:55 - 11:25 a.m. |
Dominique Madern,
CNRS-Grenoble | Unraveling Unexpected Links Between Extremophilic Adaptation and Latent Allostery Using Archaeal Malate Dehydrogenases |
Matthew Dwyer, Michigan State University | Repurposing Protein-based Organelles of Bacteria for Applications in Agriculture |
| 11:30 a.m. - 1:15 p.m. |
Plenary Awards and Closing | Grand Ballroom |
| 11:35 a.m. - 12:05 p.m. |
2026 Stein & Moore Award
Marius Clore, National Institute of Health | |
| 12:05 - 12:35 p.m. |
2026 Dorothy Crowfoot Hodgkin Award
Andreas Martin, University of California Berkeley | |
| 12:35 - 1:05 p.m. |
2026 Carl Brändén Award
Neil Osheroff, Vanderbilt University | |
| 1:05 - 1:15 p.m. |
Service Awards and Closing, Dr. Heather Pinkett, Northwestern University | President, The Protein Society |
| 2 - 4 p.m. |
Industry Visit: GINKGO BIOWORKS, (Offsite, Transportation Not Provided) (RSVP only) |
| 2:30 - 4 p.m. |
Industry Visit: JNANA, followed by Mixer, (Offsite, Transportation Not Provided) (RSVP only) |
| 2:30 - 4:30 p.m. |
Industry Visit: NOVARTIS, (Offsite, Transportation Not Provided) (RSVP only) |
| 2:30 - 4:30 p.m. |
Industry Visit: SANOFI, (Offsite, Transportation Not Provided) (RSVP only) |
